Course Category: Expert Talk

This talk presented by Dr Ee Ling Heng covers the transcatheter treatments options for valvular heart disease.

Learning Objectives

Scale of the problem
Aortic Stenosis and TAVI
Mitral Regurgitation and Edge-to-edge Repair
Tricuspid Regurgitation – the next frontier?

Dr Ee Ling Heng Background

Dr Ee Ling Heng, consultant cardiologist in adult congenital heart disease and structural intervention at the Royal Brompton and Harefield hospitals.

She graduated from Imperial College London, with an intercalated BSc in Healthcare Management. She was awarded a British Heart Foundation Clinical Research Training Fellowship and completed her PhD investigating ‘Improved Outcome Prediction in Tetralogy of Fallot’.

Dr Ee Ling Heng has clinical expertise encompassing adult congenital heart disease and general cardiology. She has a special interest in structural and ACHD interventional procedures.

This Grand Round will not only delve into the latest developments in precision medicine but also provide a platform for discussion on its application in managing respiratory diseases.

Professor Anke-Hilse Maitland-Van der Zee Background

Prof. Dr. A.H. Maitland-Van der Zee (Anke-Hilse) was trained as a pharmacist (1999 Groningen University), clinical pharmacologist and epidemiologist. She obtained her PhD in 2003 at Utrecht University and worked as a postdoc at the Human Genetics Center of the University of Texas in Houston, Tx USA from 2003-2005. From 2005-2016 she worked at the Division of Pharmacoepidemiology and Clinical Pharmacology of Utrecht University first as an assistant Professor and since 2012 an associate Professor.

In 2016 she was appointed as a full Professor of precision medicine in respiratory disease at the Academic Medical Center in Amsterdam.

This Grand Round explores a European collaborative study around childhood interstitial lung disease survivors in adulthood.

Learning Objectives

Interstitial Lung Disease (ILD) in adult vs children
International Managment platform for ILD in children child U classification

Professor Effrosyni D. Manali

Effrosyni D. Manali is Associate Professor in Athens Medical School, National and Kapodistrian University of Athens, Greece. She had completed her fellowship in Athens, Greece; Paris, France and in Cleveland, USA. She works at the 2nd Pulmonary Medicine Department of General University Hospital “Attikon”. She is the author of more than 130 peer-review articles, 19 chapter-books and participates yearly in Graduate and Postgraduate courses in Pulmonary Medicine and Internal Medicine for students and fellows. She has special interest in rare diseases of the lungs and in interstitial lung
diseases; more specifically in the study of Greek adult and pediatric patients with inheritable pulmonary fibrosis. For that purpose, she is collaborating with expert centers of excellence in Europe. She co-chaired the European Respiratory Society Task Force on transition of pediatric patients with interstitial lung disease to the adult care.

This Grand Round focuses on antenatal onset adenocarcinoma treated on ECMO.

Professor Andrew Bush has research interests that include the invasive and non-invasive measurement of airway inflammation in children, in particular the use of endobronchial biopsy in the management of severe asthma, and clinical physiology, especially respiratory mass spectrometry.
Professor Claire Hogg is a leader in clinical research in PCD and novel diagnostics. Together with her research group, Prof Hogg has developed new techniques, including 3-dimensional electron tomography and the validation of immunofluorescence for the diagnosis of PCD. Her group is the first in the world to introduce the use of Artificial Intelligence to assist the diagnosis of PCD.
Dr Michele Arigliani is a paediatric respiratory fellow at RBH. His research interests focus on lung physiology and respiratory complications in children born preterm and in those with sickle cell disease. He has co-authored over 30 papers in peer-reviewed journals.

This talk by Dr Wala Mattar, focuses on what GPs and primary care should be aware of and when they should consider referring patients to the heart failure services.

Learning objectives:

Definition of heart failure
Chronic vs acute heart failure
Heart failure with reduced ejection fraction vs preserved ventricular function
Cardiac rhythm management for heart failure with reduced ejection fraction
Multidisciplinary team management for the prevention and treatment of chronic heart failure

Dr Wala Mattar Background

Dr Wala Mattar is a consultant cardiologist, appointed at Watford General and Harefield Hospital in 2018.

Prior to this, Dr Mattar qualified from the Arabian Gulf University in the Kingdom of Bahrain in 2004, then specialised in internal medicine and cardiology. In 2011, she came to the UK to train in cardiology at Harefield Hospital. Her subspecialty interest is coronary and structural intervention and permanent pacemakers’ insertion.

.The webinar focuses on cardiac MRI guideline indications in patients with cardiovascular disease. It uses clinical cases to illustrate the role of cardiac MRI in identifying a final diagnosis, guide management and inform diagnosis.

The spectrum of pathologies discussed spans from ischemic heart disease, chest pain, myocarditis, heart failure and various non-ischemic cardiomyopathic process, as well as hypertension.

Professor Chiara Bucciarelli-Ducci Background

Professor Bucciarelli-Ducci received her undergraduate degree and postgraduate fellowship in cardiology from the University of Rome “La Sapienza”, Italy.

She then undertook courses and fellowships at various prestigious international univerisites. Professor Ducci also worked at the Royal Brompton Hospital as a senior CMR clinical and research fellow. In 2012 she was awarded a PhD in CMR from the National Heart and Lung Institute, Imperial College.

The Bristol Heart Institute and University of Bristol appointed Professor Ducci as a consultant cardiologist. In 2021 she then returned to Royal Brompton and Harefield Hospitals to lead the CMR clinical academic programme at Harefield.

This Grand Round delivered by Professor Nicholas Simmonds covers Cystic Fibrosis diagnosis and CFTR function.

More specifically this Grand Round covers:

Pathopysiology
Diagnostic pathway and uncertainties
CFTR functional tests
Case examples
CFTR related disorders
Future directions

Professor Nicholas Simmonds Background

Professor Nicholas Simmonds is Associate Director of the Adult CF Centre at Brompton and Professor of Practice (Respiratory Medicine) at Imperial College London. His main research interests include difficult CF diagnosis and the investigation of novel CF therapies. He has been a Principal Investigator on numerous global multicentre trials and is on the Executive Committee of the European Cystic Fibrosis Society (ECFS) Clinical Trials Network. He has extensive experience of novel diagnostic techniques and is the Vice Coordinator of the ECFS Diagnostic Network. He is also on the Registry Research Committee of the UK CF Registry, a role which promotes the use of registries to better understand outcomes in CF.

This Grand Round presented by Dr Stanley Hazen focuses on the microbiome: how the gut speaks to the heart.

Dr Stanley Hazen Background

Dr. Stanley Hazen received his clinical training in Internal Medicine and sub specialty training in Diabetes, Endocrinology and Metabolism at Barnes/Jewish Hospital, and a PhD in Biophysical Chemistry and Molecular Biology from Washington University School of Medicine, St. Louis, MO. He holds multiple leadership positions at the Cleveland Clinic including chair, Department of Cardiovascular & Metabolic Sciences, co-section head, Preventive Cardiology & Rehabilitation, and Director, Center for Microbiome & Human Health.

Dr. Hazen is an elected fellow to both the National Academy of Medicine, USA, and the American Association for the Advancement of Science. He also is an elected member of the American Association
of Physicians

Focusing on all aspects of general cardiology and how to manage patients and when to refer.

Learning objectives:

To gain an understanding of the workup for chest pain
To gain an understanding of the management of heart failure
To gain confidence in management of hypertension

Dr Sohaib Nazir Background

Dr Sohaib Nazir is a consultant cardiologist at Royal Brompton Hospital and clinical senior lecturer at King’s College London. He specialises in all aspects of general adult cardiology such as chest pain, breathlessness, palpitations, and general health checks for cardiovascular risk factor modification.

He has a specialist interest in heart failure and cardio-oncology – notably he is one of the few clinicians in the UK who are accredited by the International Cardio-Oncology Society, and the Royal Brompton Hospital is one of two centres in the UK with Gold accreditation by this society.

Focusing on prevention approaches in COPD (including inhaled and non-inhaled advanced therapies, use of eosinophil biomarkers etc), approaches to distinguishing viral from bacterial infections (with associated implications for antibiotic stewardship) and an update on current understanding and approaches to managing long COVID syndromes.

Learning objectives:

Options for exacerbation prevention in COPD and what we can additionally consider/offer in secondary care.
Strategies for distinguishing viral and bacterial infections and optimum treatment approaches.
Diagnosis and management of Post-COVID/Long-COVID syndromes.

Dr Aran Singanayagam Background

Dr Aran Singanayagam completed his medical training at the University of Edinburgh in 2005 achieving distinction in his final examinations alongside a first-class intercalated BSc in physiology. He trained as a respiratory doctor within north-west London, primarily at St Mary’s, Royal Brompton and Harefield hospitals.